Endocrine Abstracts

Objectives: Angiotensin II (AngII) induces renal premature senescence by multiple mechanisms including by increasing oxidative stress. Recent study revealed that growth hormone secretagogue ghrelin exerts anti-senescence effects. In this study, we examined whether ghrelin inhibits AngII-induced renal senescence and damages.Methods: Renal senescence was induced by infusion of Ang II in C57BL/6 mice with osmotic mini-pump. Ghrelin was administered by the d...

Background: Chronic kidney disease (CKD) in human has been believed to decrease muscle weight and physical performance. High protein diet would increase muscle mass and strength especially in athletes, but is not recommended for CKD patients because of the risk for exacerbation of uremia. Therefore, we investigated the muscle character especially focused on the mitochondrial activity and physical performance in 5/6 nephrectomy CKD model mice, which fed on different protein con...